Lamp2蛋白作用
TīmeklisLysosome-associated membrane protein-2 (LAMP-2)はリソソームを形成する膜に豊富に存在する、高度に糖鎖付加されたタンパク質です。. 発見当初LAMP-2の役割は ... Tīmeklis2024. gada 8. janv. · Lysosome-associated membrane protein-2 (LAMP2), is a highly glycosylated lysosomal membrane protein involved in chaperone mediated autophagy. Mutations of LAMP2 cause the classic triad of myopathy, cardiomyopathy and encephalopathy of Danon disease (DD). Additionally, retinopathy has also been …
Lamp2蛋白作用
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Tīmeklis使用人 lamp2 蛋白氨基端特异的重组蛋白对动物进行免疫接种来产生单克隆抗体。 背景 溶酶体相关膜蛋白 1 和 2（LAMP1 和 LAMP2）是两种含量丰富的溶酶体膜蛋白 … Tīmeklis2024. gada 1. janv. · LAMP2, an updated version of LAMP, holds 23 253 unique AMP sequences and expands to link 16 public AMP databases. In the current version, …
TīmeklisCells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Tīmeklis大量证据表明自噬通路在多种疾病与生理过程中起着重要作用，如：神经系统疾病、肿瘤、心血管疾病、感染、代谢性疾病、自身免疫性疾病等等，自噬通路也就成为是很多疾病潜在的靶向治疗通路。. 大隅良典因“ …
Tīmeklis2024. gada 8. dec. · Also known as Summary The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome.
TīmeklisLamp-2：溶酶体膜蛋白，可用于监测自噬体与溶酶体融合。 LysoTrackerTM 探针：有红或蓝色可选，显示所有酸性液泡。 pDsRed2-mito：载体，转染后表达一个融合蛋白（红色荧光蛋白+线粒体基质定位信号），可用来检测线粒体被自噬掉的程度（Mitophagy）。 MitoTraker探针：特异性显示活的线粒体，荧光在经过固定后还能保留。 Hsp60：定 …
Tīmeklis2024. gada 18. marts · Lamp2 KO mice receiving AAV9.LAMP2B demonstrated dose-dependent restoration of human LAMP2B protein in the heart, liver, and skeletal muscle tissue. Impaired autophagic flux, evidenced by increased LC3-II, was abrogated by LAMP2B gene transfer in all tissues in both cohorts. giant conquering hero\u0027s grave fextraTīmeklislamp2 蛋白；溶酶体关联膜蛋白 2(lamp2) 重组蛋白 原核表达秘笈：表达前的分析比什么都重要： 表达不同于其它一些实验，比如：提取质粒、 PCR 、电镜切片，这些人为 … frosty the snowman sing along songsLysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins. The protein encoded by this gene is a member of a family of membrane glycoproteins. This … Skatīt vairāk The gene for LAMP2 has 9 coding exons and 2 alternate last exons, 9a and 9b. When the last exon is spliced with the alternative exon, it is a variant called LAMP2b, which varies in the last 11 amino acids of its C … Skatīt vairāk Lysosomes are cell organelles found in most animal cells. Their main functions center around breaking down materials and debris in the … Skatīt vairāk • CA77.1 • QX39 Skatīt vairāk • Chang MH, Karageorgos LE, Meikle PJ (2003). "CD107a (LAMP-1) and CD107b (LAMP-2)". Journal of Biological Regulators and Homeostatic Agents. 16 (2): 147–51. Skatīt vairāk LAMP2 has been specifically implicated in tumor cell metastasis. Both LAMP1 and LAMP2 have been found expressed on the surface of cancerous tumors, specifically in cells of highly … Skatīt vairāk • Cluster of differentiation Skatīt vairāk • LAMP2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • PDBe-KB provides an overview of all the structure information available in the PDB for Human Lysosome-associated membrane glycoprotein 2 Skatīt vairāk giant conquering hero grave elden ringTīmeklis2024. gada 15. okt. · LAMP2 is thought to protect the lysosomal membrane from proteolytic enzymes within lysosomes and to act as a receptor for proteins to be imported into lysosomes (Fukuda, 1994).Kain et al. (2008) found that virtually all individuals with pauci-immune focal necrotizing glomerulonephritis (FNGN) had … giant connect comfort saddleTīmeklis2024. gada 24. nov. · Lamp2b-HuR融合蛋白功能化的外泌体能够将被RNA结合基序识别的RNA靶标驱动至溶酶体以在受体细胞中降解。 该系统在富含溶酶体的巨噬细胞中 … frosty the snowman sing-alongTīmeklisCMA is a selective autophagic process that depends on LAMP2A (lysosomal-associated membrane protein 2A), a mammal and bird-specific membrane glycoprotein that … frosty the snowman sing alongTīmeklis2024. gada 24. nov. · Lamp2b-HuR融合蛋白功能化的外泌体能够将被RNA结合基序识别的RNA靶标驱动至溶酶体以在受体细胞中降解。 该系统在富含溶酶体的巨噬细胞中特别有效，并作为RNA抑制的替代策略。 工程化外泌体的模式图 作为原理验证研究，RNA结合蛋白HuR与Lamp2b的C末端融合，Lamp2b是一种位于外泌体和溶酶体中的膜蛋白 … frosty the snowman silhouette