Irg1 acod1
WebACOD1 in immunometabolism and disease. Immunometabolism plays a fundamental role in health and diseases and involves multiple genes and signals. Aconitate decarboxylase 1 … WebCitraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism Citraconate inhibits ACOD1 …
Irg1 acod1
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WebJun 2, 2024 · Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism F. Chen W. A. M. Elgaher WebMar 9, 2024 · Irg1 establishes LPS-mediated tolerance to signal 2 of NLRP3 inflammasome activation (A) Design of BMDM pre-treatment with itaconate (ITA, 3 h) and classical NLRP3 inflammasome triggering: LPS priming for 3 h followed by ATP (45 min). (B and C) IL-1β protein detection in supernatants (B) or cell lysates (C) of BMDMs treated as in (A).
WebFeb 8, 2024 · Irg1 transcript induction was achieved by adding the histone deacetylase (HDAC) inhibitor valproic acid (VPA) to a histidine-tryptophan-ketoglutarate solution used … WebOct 20, 2024 · The mutant strain carrying the Acod1 em1 (IMPC) J allele (Irg1 −/−) are viable and fertile. Six- to eight-week-old male and female mice were utilized for studies. Six- to eight-week-old male ...
WebApr 1, 2024 · ACOD1 in sterile inflammatory diseases. In addition to pathogen infections, inflammation can also be triggered by tissue damage and stress, leading to various … WebFeb 10, 2024 · The immunoresponsive gene 1 (Irg-1), also known as Acod1, was first identified as a 2.3-kb cDNA from a murine macrophage cell line stimulated with lipopolysaccharide (LPS) .
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WebHere, we identify the enzyme cis‐aconitate decarboxylase 1 (ACOD1 or IRG1) and its product itaconate as protective host immune pathway in Q fever. Infection of mice with C. burnetii induced expression of several anti‐microbial candidate genes, including Acod1. In macrophages, Acod1 was essential for restricting C. burnetii replication ... how fast is 3gbWebDetroit, Michigan's Local 4 News, headlines, weather, and sports on ClickOnDetroit.com. The latest local Detroit news online from NBC TV's local affiliate in Detroit, Michigan, WDIV - … how fast is 3mbps cell phoneWebMar 15, 2024 · Download Citation IRG1/Itaconate induces metabolic reprogramming to suppress ER-positive breast cancer cell growth Most breast cancers are estrogen receptor (ER)-positive, targeted by ... how fast is 400 cc in mphWebDec 17, 2024 · ACOD1 (also known as IRG1) has emerged as a regulator of immunometabolism that operates by producing metabolite itaconate. Here, we report a key role of STING1 (also known as STING and TMEM173) in mediating ACOD1 expression in myeloid cells in response to toll-like receptor (TLR) signaling. The activation of STING1 … how fast is 4000 mphWebIrg1 is an enzyme that generates itaconate, a metabolite that plays a key role in the regulation of inflammatory responses. Previous studies have implicated Irg1 as an important mediator in... how fast is 4000 rpm in mphWebSep 21, 2024 · Recently, some studies have shown that immune responsive gene 1 (IRG1, also called ACOD1) was upregulated significantly by IFN-γ or LPS stimuli. 6 IRG1 is an enzyme that catalyzes the production of itaconate by decarboxylating cis-aconitate, which inhibits microorganism replication through itaconate and reactive oxygen species (ROS). … how fast is 370 km in mphWebJun 7, 2013 · Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species Sepsis-associated immunosuppression (SAIS) is regarded as one of main causes for the death of septic patients at the late stage because of the decreased innate immunity with a more … how fast is 3 m/s in mph