Cisplatin gdf15
WebAug 15, 2024 · The induction of GDF15 was demonstrated in vivo, and the serum level of GDF15 after cisplatin treatment was also found to be significantly up-regulated in an … WebDec 1, 2024 · We found that circulating GDF-15 is higher in subjects with cancer receiving platinum-based chemotherapy and is positively associated with weight loss in colorectal …
Cisplatin gdf15
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WebNov 7, 2024 · GDF15 is one of the major secreted proteins induced by the tumor suppressor protein p53, which acts as a growth inhibitory molecule in tumor cells. This effect is associated with the prosurvival protein activating transcription factor 3, which is negatively regulated by p53 protein expression [ 15. ]. WebFeb 2, 2024 · Elevated endogenous GDF15 is associated with energy balance disturbances, cancer progression, chemotherapy-induced anorexia, and morning sickness. We …
WebAug 1, 2024 · We first tested the ability of cisplatin to increase circulating GDF15 in mice before assessing whether GDF15 can induce behavioral fatigue measured by decreased wheel running in healthy mice and ... WebDec 1, 2024 · GDF15 is one of the major secreted proteins induced by the tumor suppressor protein p53, which acts as a growth inhibitory molecule in tumor cells. This effect is associated with the prosurvival protein activating transcription factor 3, which is negatively regulated by p53 protein expression [15].
WebNov 26, 2024 · Influence of growth differentiation factor 15 (GDF15) expression on oral squamous cell carcinoma cell sensitivity to docetaxel, cisplatin, and 5-fluorouracil treatment in vitro. Increased sensitivity (decreased cell viability) was observed in GDF15-overexpressing HB96 and HN6 cells when treated with a series of concentrations of … WebMay 25, 2024 · e24162 Background: Platinum-based drug use in cancer treatment is restricted by dose-limiting side effects, including nausea/emesis, anorexia and weight …
WebFeb 16, 2024 · 50 to 70 mg/m2 by slow IV infusion once every 3 to 4 weeks; for heavily pretreated patients, an initial dose of 50 mg/m2 by slow IV infusion once every 4 weeks …
WebApr 19, 2024 · Moreover, macrophages from these mice are deficient in release of the secretory factor growth differentiation factor 15 (GDF15), which is required for oxidative metabolism in M2-like macrophages ... high back peacock wicker chairWebSep 21, 2024 · GDF-15 is a cytokine reported to cause anorexia, aversion/emesis and weight loss in preclinical models and is associated with cancer cachexia and poor survival in patients. GDF-15 inhibition was effective to reverse weight loss, muscle and fat loss in mouse tumor models. high back picnic chairsWebOct 19, 2024 · Growth differentiation factor 15 (GDF15) expression was demonstrated to be controlled by p53 in both ovarian cancer cell lines and orthotopic mouse models. ... In addition, we showed that GDF15 expression can impact the response of both the tumor and stromal cells to cisplatin. GDF15-KD tumors had less stromal component than did … high back pfdWebNov 1, 2024 · GDF15 induces fatigue and potentiates cisplatin-induced fatigue using a 2 (+/- mGDF15-fc 1.25 mg/kg) x 2 (+/- cisplatin) factorial design with n=8 mice/group. Results: Mitochondrial... how far is johnson city tn from boone ncWebFeb 1, 2024 · GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance Cell (2024) N. Lomeli et al. Cisplatin-induced mitochondrial dysfunction is associated with impaired cognitive function in rats Free Radic. Biol. Med. (2024) L.N. Lawton et al. Identification of a novel member of the TGF-beta superfamily highly expressed in human … how far is johnsonville sc from meWebNov 1, 2024 · We first tested the ability of cisplatin to increase circulating GDF15 in mice before assessing whether GDF15 can induce behavioral fatigue measured by decreased wheel running in healthy mice and ... how far is johnson city from nashvilleWebJan 15, 2015 · Introduction Chemotherapy-related endothelial damage contributes to the early development of cardiovascular morbidity in testicular cancer patients. We aimed to identify relevant mechanisms of and search for candidate biomarkers for this endothelial damage. Methods Human micro-vascular endothelial cells (HMEC-1) were exposed to … high back pillow